Skip to main content
Premium Trial:

Request an Annual Quote

Alnylam Signs Deal with Merck to Develop RNAi Therapeutics

NEW YORK, Sept. 9 (GenomeWeb News) - Alnylam Holdings has signed on to a collaboration with Merck in order to further develop RNA interference technology and develop RNAi-based therapeutics, the companies said today.


Under the agreement, Merck will provide to Alnylam, of Cambridge, Mass., its own validated drug targets, and Alnylam will develop RNAi compounds against the targets. After the preclinical development phase, Merck and Alnylam will then decide which of the companies, or both companies, will take the compounds through the clinical development and marketing phase, the companies said.


Both companies said they will offer their resources to the collaboration, although they did not disclose the financial terms of the deal.


Alnylam has previously said it would have RNAi-based compounds in the clinic within two to three years.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.