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AIDS Researcher Retracts Findings Made with Ciphergen s ProteinChip/SELDI; Blames Sample Contamination

For an updated version of this story, click here.


NEW YORK, Jan. 23 (GenomeWeb News) - HIV researcher David Ho published a letter in today's issue of Science retracting some of the results of a 2002 paper describing the use of Ciphergen Biosystems' ProteinChip and SELDI-based proteomics platform to identify anti-HIV factors.


Ho said that although the factors identified were real, the sources of the identified proteins were not the CD8 cells, as he reported in the Nov. 1, 2002paper, but were instead contaminating neutrophils that he had used to stimulate the cells before analyzing their proteins. The neutrophils are already known to contain the identified proteins.


"We were pursuing this honestly and came up with new information which clarifies our work and the muddy areas in the field," Ho told the Wall Street Journal in an interview.


It was not immediately clear what, if any, role Ciphergen's technology may have had in the misinterpretation.


The original paper was jointly published by researchers from Ho's AaronDiamondAIDSResearchCenterat RockefellerUniversityin New York, and by researchers from Ciphergen. The retraction was authored only by the Aaron Diamond researchers.


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