NEW YORK, May 6 - Affymetrix today said it has designed a GeneChip-brand microarray for resequencing different isolates of the coronavirus that causes severe acute respiratory syndrome, or SARS.
The chip was designed using the sequence published by the Canadian team at the BC
The new array includes the entire 29,700 base pairs in the virus and is designed for rapid resequencing to study possible mutations in different isolates, according to the company. This resequencing could allow scientists to categorize these isolates into subtypes, and also, in comparing the sequence to specific clinical data, understand why some strains are more dangerous than others. Epidemiologists can also use the array to track the virus' evolution over time in different populations and different areas, the company said.
This array is part of Affymetrix CustomSeq line of arrays for pathogens and other applications.
"We hope that by getting this powerful CustomSeq array into the hands of scientists, we can contribute to understanding SARS and the search for treatments," Greg Yap, Senior Marketing Director, DNA Analysis, at Affymetrix, said in a statement.
Combimatrix has also made available a SARS microarray, and other companies have offered PCR diagnostic kits for SARS.
GenomeWeb/Newsletters' coverage of SARS
Canadian Team Sequencing SARS Virus (Apr 9, 2003)
CDC Hails SARS Virus Sequencing, Discusses PCR Diagnostic Development (Apr 14, 2003)
CDC Completes SARS Virus Genome Draft On Heels of Canadian Team (April 14, 2003)
Canadian Team Leader: SARS Coronavirus Genome Has 11 Novel ORFs (April 15, 2003)
CombiMatrix Creates Microarray Based on SARS Genome Data (April 16, 2003)
Coronavirus Linked to SARS: WHO (April 16, 2003)
Singapore Genome Institute Joins SARS Sequencing Fray (April 16, 2003)
CombiMatrix's Ali Arjomand on Developing a SARS Microarray (BioArray News, April 25, 2003)
Roche to Launch RT-PCR-based SARS Diagnostic by July (April 28, 2003)
Canadian, US, Chinese Teams Publish SARS Genome Sequence (May 2, 2003)
Focus Tech Claims First RT-PCR SARS Diagnostic (May 5, 2003)