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Affy Gets $4 Million for NCI Transcriptome Mapping Collaboration

NEW YORK, July 23-The NIH has awarded Affymetrix nearly $4 million to continue transcriptome mapping work in collaboration with the National Cancer Institute. In May, Affy and NCI researchers published in Science the early results of their work that used high-density Affymetrix microarrays to uncover hidden levels of RNA transcription activity in the human genome and hypothesized that the novel RNA transcription activity might play an important role in normal cellular operations.


Thomas Gingeras, VP of biological research at Affymetrix and senior author of the Science paper, said that the data "support an emerging view of the genome where RNA populations function in complex regulatory roles." He said the collaborators aim to evaluate the RNA populations across various cellular types throughout the human genome and to deposit the results into a public database.

The Scan

Harvard Team Report One-Time Base Editing Treatment for Motor Neuron Disease in Mice

A base-editing approach restored SMN levels and improved motor function in a mouse model of spinal muscular atrophy, a new Science paper reports.

International Team Examines History of North American Horses

Genetic and other analyses presented in Science find that horses spread to the northern Rockies and Great Plains by the first half of the 17th century.

New Study Examines Genetic Dominance Within UK Biobank

Researchers analyze instances of genetic dominance within UK Biobank data, as they report in Science.

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.