I enjoyed reading Nat Goodman’s article “Can’t Get There From Here” in the latest issue of GT (June ’03). He did well in presenting the problems of navigating not only through signaling pathways, but also through the varied websites that are attempting to represent them.
I want to point out that the AfCS-Nature Signaling Gateway does indeed contain a few pathway maps within its Molecule Page section (http://www.signaling-gateway.org/molecule/maps). It is only a modest set of pathways at the moment, but we plan on expanding the list as well as developing more dynamic ways of using them to view experimental data and linking them to the Molecule Pages.
We are also exploring new ways of representing complex pathways to make navigation easier and more meaningful (check out a recent paper we posted on the subject: http://www.signaling-gateway.org/reports/v1/DA0009.pdf). We hope to create a valuable resource for signal transduction scientists, so keep checking our site for new developments.
Gilberto R. Sambrano, PhD
System Committees Coordinator
Alliance for Cellular Signaling
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