Skip to main content
Premium Trial:

Request an Annual Quote

ABRF Seeking Participants for Recombinant Protein Expression Study

NEW YORK (GenomeWeb News) - The Association of Biomolecular Resource Facilities’ Protein Expression Research Group is inviting researchers to participate in its study of recombinant protein expression in E. coli.
 
The group’s goal is to determine the variability of results with expression and purification of a common His-tagged protein. PERG will provide researchers with a plasmid expression construct, information about the construct and encoded cDNA, and instructions regarding how to participate in the study.
 
The study is open to members and non-members of ABRF. Those new to recombinant protein expression will be given a basic protocol on how to do the expression and purification. Experienced scientists are encouraged to use their own protocols. Participants will remain anonymous but be able to see how their results compared to others and what conditions resulted in the greatest yield and purity.
 
The study will remain open until March 31. Preliminary results for data returned early will be presented at ABRF’s conference next month.
 
Further information is available here.

The Scan

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.

Study Explores Animated Digital Message Approach to Communicate Genetic Test Results to Family Members

In the Journal of Genetic Counseling, the approach showed promise in participants presented with a hypothetical scenario related to a familial hereditary breast and ovarian cancer syndrome diagnosis.

Computational Tool Predicts Mammalian Messenger RNA Degradation Rates

A tool called Saluki, trained with mouse and human messenger RNA data, appears to improve mRNA half-life predictions by taking RNA and genetic features into account, a Genome Biology paper reports.

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.