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ABI Developing New ProGroup Protein Identification Software

SAN FRANCISCO, Aug. 24 (GenomeWeb News) – Researchers at Applied Biosystems are developing a new protein identification software called ProGroup that could result in a 20 to 50 percent increase in protein identification from mass spectra, according to an ABI researcher.

ABI's Sean Seymour, who gave a presentation on the new software here at this week’s Seventh International Symposium on Mass Spectrometry in the Health and Life Sciences, said the ProGroup focuses on the inference of protein identifications from peptide identifications, rather than on peptide scoring.

“Most of the heavy algorithm work in conventional protein identification softwares goes into scoring peptides,” said Seymour . “But there’s a limit to better scoring functions, because not all peptides fragment well. What we’ve done is focus on the protein inference problem. ProGroup takes a different approach to protein identification.”

Seymour said the ProGroup software is currently in the research stage, and he does not know when it might be released.

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