ZymoGenetics, which is developing rhThrombin as an alternative to bovine plasma-derived thrombin for use as a topical hemostat, expects to market the product at the end of 2006, a company spokeswoman told GenomeWeb News.
Plasma-derived thrombin has been used as a hemostatic agent for more than 30 years, and is applied topically to surgical incisions, sutures, and burn, according to Zymogenetics. Bovine thrombin is currently the only form of thrombin that is sold in the
"Recombinant coagulation proteins have so far been accepted by the medical community as safe alternatives to plasma-derived proteins, as demonstrated by the rapid acceptance of recombinant forms of coagulation Factor VIII and Factor IX," Zymogenetics said.
Zymogenetics is a Seattle-based spin-off of Novo Nordisk.