AACR: New Drugs


At AACR, pharmaceutical and biotech companies are taking the opportunity to publicize some new and promising compounds they are testing to treat various kinds of cancer. AstraZeneca's Nigel Brooks presented AZD4547, a selective inhibitor of FGF receptors 1, 2, and 3. FGF and FGFR signaling occurs in many human tumors and controls tumor angiogenesis. According to Brooks, AZD4547 potently and selectively inhibits FGFR downstream signaling in cell lines. It has also been shown to cause dose-dependent tumor-growth inhibition in a Snu16 gastric xenograft model, he added.

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