WASHINGTON, DC (GenomeWeb News) – Sandwiched between President Barack Obama's speech on Monday at the National Academies of Science, in which he called for an "historic investment" in basic science, and the expected arrival of the White House's budget proposal for 2010, the American Association for the Advancement of Science met Thursday to discuss the past year's funding surprises and the climate of R&D spending in an uncertain economy.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.