Skip to main content
Premium Trial:

Request an Annual Quote

454 Life Sciences Uses Novel Tech to Sequence Adenovirus Genome; Data in GenBank

NEW YORK, Aug. 21 (GenomeWeb News) - 454 Life Sciences has submitted to GenBank the whole-genome sequence of adenovirus, marking the first time that a new sequence technology has been used to sequence a complete genome since 1977.


The sequence was generated in less than one day using the first technology ever designed to sequence whole genomes rather than one gene at a  time, according to 454.


454, a subsidiary of CuraGen, was required to prepare the adenovirus a single time as opposed to hundreds of sample preparations required by traditional sequencing methods.


This company's technology provided greater than 99 percent coverage of the virus, whose genome contains around 30,000 base pairs. The entire process from sample preparation to data analysis was  accomplished in less then one day, 454 said.


"We  anticipate that the commercialization of [this] technology for  sequencing whole viral and bacterial genomes may address some of the  most urgent needs in drug discovery, biodefense, and the growing  threat of emerging pathogens," Richard Begley, president and CEO of 454 Life Sciences, said in a statement.

The Scan

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.

EHR Quality Improvement Study Detects Demographic-Related Deficiencies in Cancer Family History Data

In a retrospective analysis in JAMA Network Open, researchers find that sex, ethnicity, language, and other features coincide with the quality of cancer family history information in a patient's record.

Inflammatory Bowel Disease Linked to Gut Microbiome Community Structure Gradient in Meta-Analysis

Bringing together data from prior studies, researchers in Genome Biology track down microbial taxa and a population structure gradient with ties to ulcerative colitis or Crohn's disease.

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.