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454 Life Sciences Uses Novel Tech to Sequence Adenovirus Genome; Data in GenBank

NEW YORK, Aug. 21 (GenomeWeb News) - 454 Life Sciences has submitted to GenBank the whole-genome sequence of adenovirus, marking the first time that a new sequence technology has been used to sequence a complete genome since 1977.


The sequence was generated in less than one day using the first technology ever designed to sequence whole genomes rather than one gene at a  time, according to 454.


454, a subsidiary of CuraGen, was required to prepare the adenovirus a single time as opposed to hundreds of sample preparations required by traditional sequencing methods.


This company's technology provided greater than 99 percent coverage of the virus, whose genome contains around 30,000 base pairs. The entire process from sample preparation to data analysis was  accomplished in less then one day, 454 said.


"We  anticipate that the commercialization of [this] technology for  sequencing whole viral and bacterial genomes may address some of the  most urgent needs in drug discovery, biodefense, and the growing  threat of emerging pathogens," Richard Begley, president and CEO of 454 Life Sciences, said in a statement.

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