Andrea Anderson

Using whole-genome sequencing on drug-exposed cell lines, researchers saw high mutation rates in control cell lines intermittently treated with a compound called CX-5461.

By aligning and comparing whole-genome sequences for 239 species, researchers identified regulatory elements that have become constrained specifically in primates.

Researchers flagged cannabis use disorder-associated loci in African, East Asian, European, and admixed American populations before digging into related traits and behaviors.

A simulation study suggests colonoscopy remains the most cost-effective CRC screening method, as liquid biopsy carries a far higher price per life-year gained.

Researchers searched for genetic contributors to 36 quantitative traits in Taiwan Biobank participants, comparing results to biobank data from Japan and the UK.

Researchers used single-cell RNA sequencing and other methods for the large-scale phenotyping of wild type and genetically altered mouse and zebrafish embryos.  

A homozygous version of the Christchurch variant appeared to reduce disease-related features in mouse models and cells containing a late-onset Alzheimer's-linked APOE4 mutation.

Researchers linked hospital-acquired pneumonia to altered representation of core airway microbes, while flagging pathogens in acute respiratory distress syndrome signatures.

With the help of single-cell RNA sequencing, single-cell CITE-seq, and other approaches, researchers saw six synovium-based inflammatory subtypes marked by distinct cell states.  

Using sequence data for almost 58,000 Icelanders, Decode Genetics researchers showed that actionable genotypes were associated with earlier death.