ACMG

At the ACMG annual conference in Phoenix last week, several labs and companies discussed their efforts in healthy genome sequencing.

Using monogenic diabetes registry examples, a University of Chicago researcher argued that appropriate genetic testing is needed to detect monogenic diabetes.

The organization cited ethical concerns and technological limitations surrounding CRISPR and other gene-editing approaches.

The group published a position statement today advocating for "extensive" sharing of lab and clinical data in order to improve treatment of patients.

The recommendations were developed by a working group of the AMP Clinical Practice Committee that included representatives from ACMG, ASCO, and CAP.

An ACMG workgroup has added four new genes, removed one gene, and said it would open up the nomination process to the broader community and consider PGx genes.

In a new AMP working group project, labs can volunteer to compare their interpretation of challenging variants to help identify where and how the guidelines might be improved.

The revisions, which are subject to approval by the ACMG board of directors, will likely involve the addition of five genes and the removal of one gene from the list.

The foundation, which was established by the American College of Medical Genetics and Genomics, will use the money to fund fellows' salaries and research.

In a pilot study published in AJHG, nine labs initially agreed for only 34 percent of variants, but for 71 percent after discussing the evidence and use of guidelines in detail.

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Gene drives might run into biological resistance, the Economist reports.

Forensic experts exhumed painter Salvador Dalí's body to collect DNA for a paternity test, CBS News reports.

Yale Environment 360 writes that synthetic and conservation biologists aren't always on the same wavelength, but they are trying to reach an understanding.

In Science this week: full CRISPR locus integration complex structure, and more.