Genotoxicity workflows performed manually are subject to workflow bottlenecks, where the throughput is inherently limited, and active time spent performing the tests reduces the lab’s overall efficiency. Additionally, variability associated with operator technique and laboratory conditions could lead to a loss in precision, or worse, systematic errors that can skew results. This article demonstrates automated imaging as it pertains to the comet and gamma-H2AX assays in order to simplify genotoxicity assay workflows and provide robust results.
Stringent guidelines of quality assurance and control (QA/QC) serve as the foundation for dependable and reproducible results in any analytical endeavor. Here we highlight step-by-step, the measures implemented by Myriad RBM that take Luminex xMAP technology to a high level of reproducibility and ruggedness. The Myriad RBM platform combines the sensitivity and dynamic range of microsphere-based immuno-multiplexing with the precision and dependability of automated liquid handling.
Serpins (serine protease inhibitors) regulate key intracellular and extracellular pathways, but conformational variants of this complex family of protease inhibitors are often underrepresented in proteomic analyses. This white paper from Biotech Support Group describes bead-based separation products within the NuGel family of proteomic enrichment products that enable investigations of serum serpins. Functional profiles of serpin proteoforms can then be associated with disease phenotypes, gene mutations, and dysregulated mechanisms.