Genetics, Genomics & Molecular Diagnostics News

UC can still salvage its CRISPR IP rights after last week's decision, but a long-shot appeal in federal court is the only possibility for total victory.

A genome-wide association study involving more than 52,000 men led to variants linked to male pattern baldness, along with early SNP-based attempts to predict the trait.

The RNA-based blood test takes less than five hours to detect the presence or absence of infection in patients who may have sepsis.

NanoString said its sequencing technology harnesses its expertise in optical barcodes and that it would develop it for clinical use to complement its existing products.

The company, a spinoff from genomics service provider Macrogen, plans to offer patients an exome test that screens for more than 4,000 rare diseases.

The Thermo Fisher subsidiary is not liable to Promega in the US for selling infringing forensic DNA kits in Europe, containing US-manufactured Taq polymerase.

Researchers used the approach, which analyzes somatic copy number alterations, to identify a targetable pathway, which they then blocked effectively using currently available drugs.

Researchers used the approach, which analyzes somatic copy number alterations, to identify a targetable pathway, which they then blocked effectively using currently available drugs.

The Thermo Fisher subsidiary is not liable to Promega in the US for selling infringing forensic DNA kits in Europe, containing US-manufactured Taq polymerase.

In Genome Biology this week: comparative genomics study of Aspergillus, genetic variation in indigenous African cattle, and more.

Some people who harbor genetic variants associated with disease show no signs and may give insight into the continuum of symptoms, Spectrum reports.

Some 57 snow monkeys at a Japanese zoo were found to be rhesus macaque hybrids, which are banned in Japan.

British researchers say they've been removed from EU grant applications, according to the Guardian.

Genotoxicity workflows performed manually are subject to workflow bottlenecks, where the throughput is inherently limited, and active time spent performing the tests reduces the lab’s overall efficiency. Additionally, variability associated with operator technique and laboratory conditions could lead to a loss in precision, or worse, systematic errors that can skew results. This article demonstrates automated imaging as it pertains to the comet and gamma-H2AX assays in order to simplify genotoxicity assay workflows and provide robust results.

Stringent guidelines of quality assurance and control (QA/QC) serve as the foundation for dependable and reproducible results in any analytical endeavor. Here we highlight step-by-step, the measures implemented by Myriad RBM that take Luminex xMAP technology to a high level of reproducibility and ruggedness. The Myriad RBM platform combines the sensitivity and dynamic range of microsphere-based immuno-multiplexing with the precision and dependability of automated liquid handling.

Serpins (serine protease inhibitors) regulate key intracellular and extracellular pathways, but conformational variants of this complex family of protease inhibitors are often underrepresented in proteomic analyses. This white paper from Biotech Support Group describes bead-based separation products within the NuGel family of proteomic enrichment products that enable investigations of serum serpins. Functional profiles of serpin proteoforms can then be associated with disease phenotypes, gene mutations, and dysregulated mechanisms.