Genetics, Genomics & Molecular Diagnostics News
Ruedi Aebersold

GenomeWeb spoke to Aebersold this week from New York to get his thoughts on the meeting and what is happening in the world of proteomics more generally.

The bill, which would boost NIH funding among other things, was overwhelmingly approved by the House and cleared a Senate subcommittee, but has stalled amid negotiations over appropriations.

The firm's technology, called genotyping by random amplicon sequencing, or GRAS, should improve the efficiency of identifying and selecting markers for crop improvement.

The new company believes it can be the dominant clearinghouse for genome analysis apps or other tools, with free and unlimited storage of users' genomic data.

In Nature this week: genetic link between birth weight and adult-onset diseases, and more.

Even with all the current enthusiasm for gene therapies, Tech Review cautions that they are mostly in the early stages of development.

DNA phenotyping puts a potential face to a suspect in a nearly 25-year-old murder, the AP reports.

Researchers discuss the need for antibody standards at a meeting, NPR reports.

Genetic analysis of single nucleotide polymorphisms must be accurate, reliable and economical to be a viable part of human genetic research, drug discovery, and diagnostics. This study demonstrates the ability of the IntelliQube, a fully integrated liquid handling and real-time quantitative PCR instrument, to successfully multiplex SNP assays in a single well and decrease thermal cycling times without compromising data quality.

This white paper offers advice from two industry experts, Jill Northup from Medical College of Wisconsin, and Philip Cotter from ResearchDx, on setting up a clinical NGS laboratory. The paper covers the general principles of CLIA certification and their specific application to clinical NGS, as well as considerations on implementing informatics to support validated workflows.

Next-generation sequencing (NGS) of bisulfite-converted DNA to detect methylation status with per-base resolution is currently restricted by input requirements, requiring at least 50 ng of DNA. This Application Note shows how the unique chemistry of the Accel-NGS Methyl-Seq DNA Library Kit enables the construction of high complexity libraries for:

•      Genome-wide methylation analysis from 5 ng of human cell-free DNA (cfDNA).