Genotoxicity workflows performed manually are subject to workflow bottlenecks, where the throughput is inherently limited, and active time spent performing the tests reduces the lab’s overall efficiency. Additionally, variability associated with operator technique and laboratory conditions could lead to a loss in precision, or worse, systematic errors that can skew results. This article demonstrates automated imaging as it pertains to the comet and gamma-H2AX assays in order to simplify genotoxicity assay workflows and provide robust results.
Stringent guidelines of quality assurance and control (QA/QC) serve as the foundation for dependable and reproducible results in any analytical endeavor. Here we highlight step-by-step, the measures implemented by Myriad RBM that take Luminex xMAP technology to a high level of reproducibility and ruggedness. The Myriad RBM platform combines the sensitivity and dynamic range of microsphere-based immuno-multiplexing with the precision and dependability of automated liquid handling.
Single cell analysis has become increasingly important in translational research allowing scientist to study cell-to-cell variations within a cell population. However, the current flow cytometry protocols are limited to 16-20 protein biomarkers and samples are stable for only 1-5 days. In this White Paper we present an overview on assays, instrumentation and applications of the high parameter ChipCytometry platform and the ability to store clinical samples for a period of 24 months at full biomarker integrity.