Investigators using droplet digital PCR methods are following cell-free tumor DNA in the blood, looking for patterns coinciding with immunotherapy treatment outcomes.
Researchers used the approach to develop an assay to detect above-threshold triplet repeats in Huntington's disease, but also highlight a variety of other applications.
With discovery and replication meta-analyses on data for more than 100,000 individuals, researchers identified variants that influence lean mass near five genes.
The researchers suggested that Ashkenazi Jewish women as well as women of other ancestries might benefit from broader genetic screening for breast cancer risk.
A former Penn State Hershey Medical Center staffer has admitted to lying about skipping mandatory steps of genetic cancer tests he performed, the Associated Press reports.
Whatever practices you use for NGS assay development, validation, and performance monitoring, your goal is the same: Your results must be as accurate, precise, and consistent as possible.
That goal is within reach. And in this paper, we’ll show you how. By reading this white paper, you will learn:
· Why quality control is so challenging for NGS labs
· How reference materials may be the key to quality control
· The 9 key characteristics of sufficient NGS reference materials
· How to use QC metrics to monitor the health of your NGS assays
What’s been holding back more widespread adoption of liquid biopsy testing?
Lack of adequate circulating tumor DNA reference materials for developing and measuring safe, accurate and reproducible assays has been a challenge for clinical labs
Liquid biopsies are poised to revolutionize cancer diagnosis and therapy, but until now, advances in diagnostic technology - particularly at the low end of the sample input and sensitivity spectrum - have been hampered by the lack of ability of labs to reproducibly measure and assess the assay’s performance.
