GenomeWeb Video | Videos

A Conversation with Robert Chalkley at ABRF

In this video, Adam Bonislawski, editor of ProteoMonitor, caught up with UCSF's Robert Chalkley at the recent Association of Biomolecular Resource Facilities meeting in Orlando, Fl. Chalkley, who is also chair of ABRF's Proteomic Informatics Research Group, discusses the challenge at this year's meeting — identifying post-translationally modified peptides in a complex background — and more.

April 19, 2012 / GenomeWeb Video

Collaborative Effort Targets Alzheimer's Disease

We dropped by the Feinstein Institute for Medical Research in Manhasset, New York, for a conversation with Peter Davies, director of the Litwin-Zucker Center for the Study of Alzheimer's Disease and Memory Disorders. Davies is heading up a collaboration between the Feinstein Institute, the New York Genome Center, and Illumina that aims to uncover the genetic basis of Alzheimer's disease.

March 26, 2012 / GenomeWeb Video

Randall Nelson at MSCAL 2012

In this video, we sat down with Randall Nelson, research professor at Arizona State University's Biodesign Institute, at the Mass Spectrometry: Applications to the Clinical Laboratory 2012 meeting in San Diego. Nelson speaks about mass spectrometry immunoassay (MSIA) technology and protein heterogeneity, the challenges associated with moving mass spec into the clinic, and more.

March 19, 2012 / GenomeWeb Video

Leigh Anderson at MSACL 2012 Part II

This is part two of a conversation with Leigh Anderson, CEO of SISCAPA Assay Technologies, at the Mass Spectrometry Applications to the Clinical Laboratory 2012 meeting in San Diego, California.

March 13, 2012 / GenomeWeb Video

Leigh Anderson at MSACL 2012 Part I

This is part one of a conversation with Leigh Anderson, CEO of SISCAPA Assay Technologies, at the Mass Spectrometry Applications to the Clinical Laboratory 2012 meeting in San Diego, California.

March 13, 2012 / GenomeWeb Video

AGBT 2012 Part II

This video from AGBT 2012 includes comments from Washington University's Elaine Mardis and Baylor College of Medicine's Donna Muzny — among others — on clinical applications of emerging sequencing technologies, desktop sequencing, and more.

March 08, 2012 / GenomeWeb Video

Tri-Con 2012

We caught up with Harry Glorikian, founder and managing partner at Scientia Advisors, at this year's Tri-Con 2012 in San Francisco, California. Glorikian provides his views on current challenges for molecular diagnostics developers, sequencing in the clinic, clinical decision support systems, and more.

March 02, 2012 / GenomeWeb Video

AGBT 2012 Part 1

In Sequence and Clinical Sequencing News editor Julia Karow gets reactions from attendees at this year's Advances in Genome Biology & Technology meeting in Marco Island, Florida.

February 24, 2012 / GenomeWeb Video

ScienceOnline2012

Genome Technology's Tracy Vence interviewed Sandra Porter, president of Digital World Biology, and Kristi Holmes, a bioinformaticist at the Becker Medical Library, Washington University School of Medicine at ScienceOnline2012 .

February 02, 2012 / GenomeWeb Video

Sponsored Video: Ambry Genetics - "Fully-Automated"

RainDance's ThunderStorm System is a fully-automated and walkaway high-throughput targeted sequencing solution that enables researchers to process 96 samples per day run on a proven platform that generates higher-quality data faster than ever before.

February 01, 2012 / Sponsored Videos

GenomeWebinars

Advances in Single-Cell Genomics: Live Cell RNA and Circulating miRNA Detection

Sponsor: EMD Millipore

Data presented in this webinar illustrates the value of live cell analysis at the single-cell level to identify differences in expression levels across populations of cells. The cells remain intact for downstream analysis. Our experts also discuss the use of SmartFlare RNA detection probes for the direct quantification of circulating miRNAs with rapid processing of blood plasma/serum, which is done without the use of enzymes. Using circulating miRNAs with established roles in cancer and quality control, we can accurately detect these miRNAs in plasma using a microplate fluorometer within an hour after plasma preparation.

On-demand recording is available here.

Optimization of NGS Library Preparation: Low Inputs and Fast, Streamlined Workflows

Sponsor: New England Biolabs

Library preparation methods continue to be challenged by the requirement for faster and more efficient protocols, using lower input amounts. In this online seminar, recorded Feb. 7, 2013, experts discuss new approaches to tackle these challenges, particularly for bacterial and exome sequencing.

Available here.
Young Investigator Profile

Lei Xie

Associate Professor
City University of New York

Changing Approaches in Drug Development

After finishing his postdoc, Lei Xie started working at a pharmaceutical company where he saw firsthand the weaknesses of the one-drug-one-gene-one disease approach. Upon leaving industry, Xie returned to academia, set upon finding ways to improve the success rate of investigational treatments through so-called polypharmacology, an approach that aims to advance drugs that target disease-causing networks instead of inhibiting individual receptors.

In his research at CUNY's computational systems biology, molecular modeling, and bioinformatics lab, Xie aims to identify the targets of drugs across the whole genome and then map them into biological pathways and networks.
Blog

Moriguchi's at it Again

Hisashi Moriguchi now says he has supercooled oocytes as well as used iPS cells to treat liver cancer and heart failure, but the Nature News blog isn't so sure.

Who's an Author?

To be included on the author list, investigators should meet certain criteria.

Difficulties After the Freeze

A new survey says that UK researchers are experiencing funding and recruiting issues as the science research budget is kept flat.

Now the Fastest

The current fastest supercomputer is China's Tianhe-2, Top500 says.
Papers of Note

Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us
El Baidouri, Diancourt, et al. PLOS Neglected Tropical Diseases

Through a multilocus sequence analysis of 222 African and Eurasian Leishmania isolates, French researchers identified seven genetic clusters of Leishmania in the regions tested. For the most part, those clusters corresponded to existing Leishmania classification schemes, the study authors note, though their analysis suggests genetic distinctions are somewhat hazier for three Leishmania species implicated in visceral forms of leishmaniasis. "Although these taxa cause specific clinical forms of the disease and are maintained through different parasitic cycles," they say, "they are not clearly distinct and form a continuum, in line with the concept of species complex already suggested for this group thirty years ago."

Evolutionary changes of multiple visual pigment genes in the complete genome of Pacific bluefin tuna
Nakamura, Mori, et al. Proceedings of the National Academy of Sciences

AJapanese team describes findings from a genome sequencing study focused on the Pacific bluefin tuna, Thunnus orientalis. An analysis of the genome revealed more than 26,400 predicted protein-coding genes, including genes coding for rhodopsin and opsin pigments poised to pick up blue, green, red, and UV light. Within genes coding for the color-sensing proteins, researchers found substitutions and duplications suspected of helping bluefish tuna differentiate between blue and green. If so, that could confer an evolutionary advantage in the fish's ocean environment, they say, perhaps explaining some aspects of the tuna's predatory proficiency.
People on the Move

Direct-to-consumer genetic testing firm 23andMe has appointed Andy Page as its president, a newly created post. Page, who has served as a member of 23andMe's board of directors for the past year, will report to CEO and co-founder Anne Wojcicki. He was previously president of the Gilt Groupe, an online luxury shopping website, and chief operating and financial officer at PlayPhone.

The Ludwig Institute for Cancer Research has appointed David Lane to be its new scientific director, effective June 1. He succeeds Andrew Simpson, who was scientific director for five years, from 2007 to 2012. Lane is chief scientist at Singapore's Agency for Science, Technology, and Research, and he will retain that post in addition to his new role at Ludwig.

Kevin Hrusovsky is resigning his post at PerkinElmer as senior VP and president of the Life Science and Technology division. Hrusovsky will serve as a consultant to the company for up to one year, beginning in June. He joined PerkinElmer through the company's acquisition of Caliper Life Sciences, where he was CEO and president.
Upcoming Events

Conferences, Meetings & Deadlines

International Meeting on Cell-Free DNA
June 20-21 / Copenhagen
Copenhagen University Hospital

Intelligent Systems for Molecular Biology
July 21-23 / Berlin
International Society for Computational Biology

2013 AACC Annual Meeting
July 28-August 1 / Houston
American Association for Clinical Chemistry

NGS for Drug Developers
July 31-August 2 / Boston
Wyss Institute

Cancer Cytogenomics Microarray Consortium meeting
August 5-7 / Chicago
Cancer Cytogenomics Microarray Consortium

Abstract & Registration Deadlines

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Science
An international research team has uncovered unexpected genetic diversity in the miniscule marine algae Emiliania huxleyi, a species now known to have the type of variable 'pan genome' previously described in some bacterial species. They detected an array of genes and repetitive sequences that are present in some E. huxleyi strains but not in others, varying with each strain's habitat, physical features, and metabolic capabilities, among others.
Business
The US Supreme Court unanimously ruled that human genes are not patentable, but synthetic DNA, or cDNA, is patent eligible because it does not occur naturally. Its decision had broad implications for the biotech industry and for Myriad Genetics, in particular, whose patents on the BRCA1 and BRCA2 genes were at the center of the case. The ruling runs counter to the US Patent and Trademark Office's policy of granting patents on isolated gene sequences.
Funding
The US investment in the Human Genome Project and the ensuing federal funding for genome science has reaped massive economic benefits, according to a new study from Battelle. It found that genomics-related fields from biomedicine to energy and agriculture have had a $965 billion impact on the US economy, stemming from a total of $14.5 billion in federal investments between 1988 and 2012. Genomics-related funding has yielded a $65 return on every $1 invested.
GenomeWebinars
GenomeWebinar: Advances in Single-Cell Genomics: Live Cell RNA and Circulating miRNA Detection

Sponsor: EMD Millipore

GenomeWeb and EMD Millipore invite you to view an archived webinar discussing new approaches to detect RNA at the single-cell level as well as new probes for the direct quantification of circulating miRNAs. In this free online seminar, recorded April 25, 2013, our expert panel shares protocols for improved RNA and miRNA detection.

On-demand recording available here.

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