KCTD13 a Driver of Neurodevelopmental Phenotypes Associated with the 16p11.2 CNV
Golzio, Willer et al., Nature
An international team led by investigators at Duke University shows that KCTD13 "is a major driver for the neurodevelopmental phenotypes associated with the 16p11.2 CNV [copy-number variant]," a finding that it says substantiates "the idea that one or a small number of transcripts within a CNV can underpin clinical phenotypes, and offer an efficient route to identifying dosage-sensitive loci."
Study Suggests Yeast Ribosomal RNA Genes Boost Genome Stability
By comparing Saccharomyces cerevisiae strains with between 20 and 110 copies of rDNA genes, Japanese researchers identified mechanisms through which these sequences help protect the genome following DNA damage.
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