Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Consortium Expects Completed Turkey Genome to Usurp Chicken as Avian Reference
The turkey genome sequencing project began last year as a pilot study using the Roche GS-FLX platform. Recently, the group joined forces with two additional teams: USDA researchers who are using the Illumina platform, and a bioinformatics group at the University of Maryland.
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