Regulation and Function of miR-218 in Gastric Cancer Metastasis
Tie, Pan et al., PLoS Genetics
Researchers describe a negative feedback system between Robo1, a Slit receptor, and miR-218, wherein “decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis.” The authors suggest that the restoration of miR-218 supresses Robo1 espression and inhibits tumor cell invasion.
Two Teams Devise New Methods for Sequencing-Based Methylation Profiling
Both groups published methods that use padlock probes to target large numbers of loci containing CpG sites. In addition, one group developed a genome-wide approach that relies on a methylation-sensitive restriction enzyme.
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