Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Team Publishes Paper on 10K Vertebrate Species Sample Collection Effort
The Genome 10K Community of Scientists, from research institutes, museums, and zoos around the world, are assembling a sample collection containing more than 16,000 vertebrate species in preparation for future whole-genome sequencing studies.
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