An international team, led by Max Planck Institute for Evolutionary Anthropology Director Svante Pääbo, used specialized DNA extraction and enrichment methods to sequence a nearly complete mitochondrial genome from a 400,000-year-old hominin's thigh bone — believed to be the oldest non-permafrost sample successfully sequenced so far. As they reported in Nature, researchers' phylogenetic assessments at the mtDNA sequences suggested that the ancient individual belonged to a mitochondrial lineage that split from the Denisovans roughly 700,000 years ago.
23andMe was hit with a class action lawsuit just a few days after the US Food and Drug Administration told the firm that it must stop marketing its spit test and genome service to consumers because it has failed to address FDA's questions about the clinical and analytical validity of the product. The suit alleges that 23andMe "falsely and misleadingly" advertises its services as providing health reports on 240-plus conditions and traits as well as other information, such as carrier status, "when there is no analytical or clinical validation for the PGS for its advertised uses."
The UK government and Genomics England are collaborating to award £10 million ($16.4 million) to small businesses seeking to develop genomic analysis technologies. For phase I efforts, the partners plan to provide grants of up to £200,000 for six-month projects, and only those that complete this phase will be eligible for phase II funding, which is generally used to develop and evaluate prototypes or demonstration units. The funding call will run alongside the 100K Genomes Project, a five-year effort to sequence and analyze 100,000 patients, or infections in patients.
GenomeWeb and Asuragen invite you to view a webinar discussing the use of next-generation sequencing to illuminate druggable targets in oncology while addressing the limitations in DNA quality and yield from formalin-fixed specimens.
Register here to view the playback or download the recording.