Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Study Suggests Malaria Resistance Variants Have Comparable Role in Different Parts of Primate Lineage
A team of scientists from Duke University and the Institute of Primate Research at the National Museums of Kenya reported in Nature today that resistance to malarial parasites and related pests apparently arose in a similar manner in humans and baboons.
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