Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Researchers Develop Method for Distinguishing Ancient Human DNA from Modern Day Contaminants
German and Russian researchers used information from Neandertal sequences to distinguish ancient human DNA from modern day contaminants and applied this approach to sequence the mitochondrial genome from 30,000-year-old human remains.
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