Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Researchers Combine Sequencing, CGH Arrays to Analyze and Annotate a Korean Genome
Researchers used a combination of whole-genome shotgun sequencing, targeted bacterial artificial chromosome sequencing, and microarray-based comparative genomic hybridization analysis to analyze and annotate the genome.
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