Penn State Team Uses 454 Reads to Develop SNP-Calling Method for Endangered Species

December 02, 2008

By Julia Karow

Under a $1 million grant from the Gordon and Betty Moore Foundation, Penn State scientists have sequenced the genomes of two Tasmanian devils at low coverage on 454’s platform. Using new computational tools that do not require a reference genome, they have discovered SNPs that they hope will help their Australian colleagues select cancer-resistant devils for breeding.

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Researchers from the Institute for Systems Biology and elsewhere used Complete Genomics' sequencing service to identify mutations behind a Mendelian condition called Miller syndrome and an inherited lung disorder called ciliary dyskinesia in a family of four.
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Penn State Team Uses 454 Reads to Develop SNP-Calling Method for Endangered Species

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