PacBio Stakes Claim in Single-Molecule Long-Read Sequencing by Acquiring Li-Cor Tech

June 03, 2008

By Julia Karow

Li-Cor’s single-molecule sequencing technology uses so-called charge-switch nucleotides that carry a label at the gamma-phosphate position, and complements Pacific Biosciences’ own single-molecule real-time sequencing approach.

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Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
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Genetic Data for Modern Genetic Breeds 'Have Yet to Shed Light on Dog Origins'
Larson, Karlsson et al., PNAS
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Genome Technology Magazine
More than a decade ago, fluorescent reporter studies highlighted the stochastic nature of gene expression, and biologists then began to examine the phenotypic heterogeneity they saw in clonal cell populations, through they chalked up what they saw to noisiness in gene expression. Still, researchers wondered about the cause of the randomness they had observed. Now, biophysicists and systems biologists are looking into that question and aim to figure out how and why single cells and molecules behave the way they do, and the consequences of that behavior.

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PacBio Stakes Claim in Single-Molecule Long-Read Sequencing by Acquiring Li-Cor Tech

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