Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
PacBio Proof-of-Concept Paper Sheds Additional Light on SMRT Technology
The paper, published two weeks ago in Science, reveals previously undisclosed details relating to the surface and nucleotide chemistry. Since writing the article, the company has improved the technology, including its read length, accuracy, and degree of multiplexing.
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