Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Nearing 100 Orders, ABI Says SOLiD System Claims 40 Percent of Second-Gen Purchases
Since the launch of SOLiD 2.0, the platform’s first upgrade, in May, demand for the sequencer has picked up, and ABI believes it is now taking about 40 percent of all new orders for second-generation sequencing systems. The company is working on improving the SOLiD’s throughput, developing new software for several applications, and shortening the time to reach customer acceptance.
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