Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
NCI Awards $23.6M to Genome Characterization, Data Analysis Centers in FY '09 for Expanded Cancer Genome Atlas
The six Genome Characterization Centers, which received a total of $16.6 million in fiscal year 2009, plan to use next-generation sequencing at least for part of their work. They will characterize genomic changes in tumors, such as alterations in miRNA and gene expression, SNPs, epigenetic changes, and copy number alterations.
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