Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
JGI’s 2009 Community Sequencing Program Marks Shift from Sanger to New Platforms
For next year’s CSP, which accounts for about half of JGI’s sequencing activities, the institute has selected 44 projects, including genomes of eukaryotes, bacteria, and archaea, as well as metagenomic analyses. More than half of the sequencing data will be generated on Illumina’s Genome Analyzer, about a quarter on 454’s platform, and less than 15 percent by Sanger sequencing.
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