Regulation and Function of miR-218 in Gastric Cancer Metastasis
Tie, Pan et al., PLoS Genetics
Researchers describe a negative feedback system between Robo1, a Slit receptor, and miR-218, wherein “decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis.” The authors suggest that the restoration of miR-218 supresses Robo1 espression and inhibits tumor cell invasion.
Intelligent Bio-Systems Plans to Debut Its Sequencing-by-Synthesis Tool Next Year
The company, which has placed one prototype instrument in an undisclosed genome center and is currently looking for other early-access customers, said its long-term goal is to break into the clinical sequencing market.
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