Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Independent Studies Use Illumina GA To Sequence Three Human Genomes
The three studies — analyzing the genomes of a HapMap sample of African origin, a Han Chinese individual, and a leukemia patient — are the first published genomes sequenced on the Illumina Genome Analyzer and increased the number of peer-reviewed individual human genomes from two to five.
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