Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Helicos Publishes M13 Genome Re-Sequencing Data, Promises More Single-Molecule Studies
The researchers, who re-sequenced the 6.4-kilobase M13 virus using an earlier version of Helicos’ technology, observed problems with long homopolymers and deletion errors. However, the study demonstrates that single-molecule sequencing is possible, and that the data quality is sufficient for several research applications.
New to GenomeWeb? Register quickly here.