Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Harvard's Hybridization Capture Method Promises Flexibility, Low Cost, CNV Detection
The researchers claim that their method, published in Nature Methods this week, is less expensive and more flexible than existing array- or solution-based targeted enrichment methods. They also demonstrate that it can be used both for calling SNPs and detecting copy number variations.
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