Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene
Kapur et al., PLoS Genetics
An international team of researchers reports its genome-wide association study of serum calcium's association with SNPs in or near the calcium-sensing receptor gene on 3q13. "This genome-wide meta-analysis shows that common CASR variants modulate serum calcium levels in the adult general population," the researchers write, adding that their "results show that CASR is a key player in genetic regulation of serum calcium in the adult general population."
'Footprint' Approach Maps Regulatory Protein Binding
Using a combination of DNase I cleavage and massively parallel sequencing, University of Washington researchers used an approach they call "digital genomic footprinting" to find and characterize protein-binding sites in the yeast genome.
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