Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
DNA in Alaskan Permafrost Offers Insights into Mammoth Extinction
An international research team has detected mitochondrial DNA sequences from mammoths and prehistoric horses in 7,600 to 10,500 year old soil samples from central Alaska, causing researchers to rethink when — and how — mammoths and other large animals became extinct.
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