Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Complete Genomics to Receive $1.1M for Sequencing 50 Tumor-Normal Pairs in NCI Pediatric Cancer Study
The project is part of an NCI initiative called Therapeutically Applicable Research to Generate Effective Treatments, which seeks to use genomic technologies to rapidly identify therapeutic targets in childhood cancers.
New to GenomeWeb? Register quickly here.