Cancer Genomics Paradigm Begins to Shift as Scientists Adopt Whole-Genome Sequencing

Using the example of an AML genome that her center recently sequenced on the Illumina Genome Analyzer, Elaine Mardis, co-director of the Genome Center at Washington University in St. Louis, showed how this approach can uncover mutations in genes that are part of known cancer pathways but were not included in previous lists of cancer candidate genes. The research has spawned similar studies at Wash U and elsewhere for this and other cancers.

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