Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
BGI-Led Project Uses Mix of Illumina and Sanger Sequencing to Assemble Cucumber Genome
November 03, 2009
The hybrid approach, which used a small amount of Sanger and a large amount of Illumina sequencing data, improved the contig and scaffold length and the fraction of the overall genome assembled, compared to either technology alone. It might be useful for other projects, the researchers suggested, though it will depend on the nature of the genome under study.
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