Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
1000 Genomes Project to Sequence Nearly 1,000 More Samples by Early 2010; New Samples Collected
Following three pilot projects, results of which are currently being analyzed, the project expects to sequence an additional 985 samples at 4x coverage by early 2010. One of the pilots, designed to test three second-generation sequencing technologies, showed that all three produce data that is suitable for the project.
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