Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Sanford-Burnham Promotes Vuori to President as Reed Focuses More on Externals
The move will allow Reed to focus more of his efforts outside Sanford-Burnham's campuses in La Jolla, Calif., and in the Lake Nona community of Orlando, Fla., according to a spokesman for the institute.
New to GenomeWeb? Register quickly here for free access.