Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
UMMS RNA Therapeutics Institute Aims to Bring Researchers Together, While Looking to RNAi and Beyond
The RTI hopes to create synergies between investigators focused on basic science researchers and those oriented towards the clinic by putting them in the same space. At the same time, the institute aims to foster research that encompasses all RNA-related pathways, not just RNAi.
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