Q&A: MSKCC's Hans-Guido Wendel on Developing an Unbiased Screen for microRNA Targets

Wendel and colleagues used a short hairpin library screen to identify genes whose knockdown mimicked the effect of microRNA-19, a member of the oncogenic miR-17-92 cluster, in lymphocytes, hypothesizing that this would reveal the genes responsible for the miRNA's activity.

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