Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
MDRNA Unveils New RNAi Pipeline, Reports Q2 Financials Amid Ongoing Restructuring
The latest phase of the restructuring will include the termination of another 23 employees, primarily in MDRNA’s nasal programs, which will reduce the company’s overall headcount to 55. Among those positions eliminated in the newest round of layoffs are three executives.
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