Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
MDRNA Eyes Second 'Early Collaborative Effort' Before Year-End, Large Alliance in 2010
Meanwhile, work on MDRNA’s liver and bladder cancer programs proceeds apace, and the company continues to expect it will file its first investigational new drug application before the end of next year.
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