Gradalis Pushes Back shRNA Rx Trial to Evaluate Delivery, Expression Tech

February 19, 2009

By Doug Macron

According to a company official, after having tested the drug's delivery vehicle and expression plasmid separately in humans with gene therapies, Gradalis is now on track to file an investigational new drug application for the shRNA treatment later this year.

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Genome Technology Magazine
More than a decade ago, fluorescent reporter studies highlighted the stochastic nature of gene expression, and biologists then began to examine the phenotypic heterogeneity they saw in clonal cell populations, through they chalked up what they saw to noisiness in gene expression. Still, researchers wondered about the cause of the randomness they had observed. Now, biophysicists and systems biologists are looking into that question and aim to figure out how and why single cells and molecules behave the way they do, and the consequences of that behavior.

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Gradalis Pushes Back shRNA Rx Trial to Evaluate Delivery, Expression Tech

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