Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Cell-Cell Contact Leads to Global Rise in MicroRNA Levels
Using microarray and Northern blot analyses, Johns Hopkins University researchers discovered that the levels of almost all miRNAs increases following cell-cell contact in Drosophila and mammalian cell lines, regardless of whether these cells display contact inhibition.
New to GenomeWeb? Register quickly here for free access.